Membrane Lung Functional Assessment v8

Output language aligned with Zakhary et al., Critical Care (2020). This tool is decision support and does not replace clinical judgment.

How to assess adequate gas transfer (in-app checklist)
  1. Confirm sampling: simultaneous pre- and post-membrane lung blood gases from correct ports; minimise delay.
  2. Standardise “stress test” conditions to interpret oxygen transfer:
    • Set FDO₂ = 100% and increase sweep to ≥ 10 L/min (if clinically appropriate).
    • Recheck post-membrane lung gas and recalculate V′O₂.
  3. Interpret V′O₂ in context:
    • V′O₂ depends on Hb and pre-/post-oxygenator saturation. Low Hb reduces measured V′O₂ even with a normally functioning membrane lung.
    • Compare against prior V′O₂ at similar Hb and blood flow; use trends rather than a single value.
  4. Integrate other domains: hydraulic trends (RML = ΔP/BFR), venous pressure (drainage limitation), CO₂ clearance, and haemolysis.

Gas Transfer Inputs

Oxygenator Settings

“Maximal” conditions in this tool: Sweep ≥ 10 L/min and FDO₂ = 100%.

Pressure Monitoring (single timepoint)

More negative values suggest increased drainage limitation (context-dependent).

Haematologic / Haemolysis Profile

Hydraulic Trend (flexible number of points)

Add as many points as you want. Enter a timestamp for each row. The tool will sort by time from oldest → newest before evaluating trends, so there is no ambiguity about “Hour 1”.

Tip: if you don’t have exact times, enter approximate times in correct order.
Time (local) Blood Flow (L/min) Pump RPM ΔP (mmHg) Venous pressure (mmHg)

Results will appear here after you press Assess Membrane Lung. You may adjust values and press the button again without reloading the page.